Article
Alterations in the growth hormone/insulin-like growth factor I pathways in feline GM1 gangliosidosis.
Endocrinology - 1 Dec 1999
Cox N R, Morrison N E, Sartin J L, Buonomo F C, Steele B, Baker H J
Abstract excerpt
Cats affected with feline GM1 gangliosidosis, an autosomal, recessively inherited, lysosomal enzymopathy, have progressive neurological dysfunction, premature thymic involution, stunted growth, and premature death. Although increased membrane GM1 gangliosides can result in increased apoptosis of thymocytes, there is not a direct correlation between thymocyte surface GM1 and thymic apoptosis in vivo, suggesting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.