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Article

Phenotypic correction of feline lipoprotein lipase deficiency by adenoviral gene transfer.

Human gene therapy - 1 Jan 2000

Liu G, Ashbourne Excoffon K J, Wilson J E, McManus B M, Rogers Q R, Miao L, Kastelein J J, Lewis M E, Hayden M R

Abstract excerpt

Previous studies have revealed that adenovirus-mediated ectopic liver expression of human LPL (huLPL) can efficiently mediate plasma triacylglycerol (TG) catabolism in mice despite its native expression in adipose and muscle tissue. We aimed to explore the feasibility of liver-directed gene transfer and enzyme replacement for human LPL deficiency in a larger, naturally occurring feline animal model of complete...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10646636
DOI: 10.1089/10430340050016120

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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