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Article

Mutation rates in humans. II. Sporadic mutation-specific rates and rate of detrimental human mutations inferred from hemophilia B.

American journal of human genetics - 1 Dec 1999

Giannelli F, Anagnostopoulos T, Green P M

Abstract excerpt

We estimated the rates per base per generation of specific types of mutations, using our direct estimate of the overall mutation rate for hemophilia B and information on the mutations present in the United Kingdom's population as well as those reported year by year in the hemophilia B world database. These rates are as follows: transitions at CpG sites 9.7x10-8, other transitions 7.3x10-9, transversions at CpG...

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Identifiers

PMID: 10577911
DOI: 10.1086/302652
PMCID: PMC1288368

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