Article
Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures
10 Nov 2010
Abstract excerpt
BACKGROUND: Glioblastomas (GBM), the most frequent malignant brain tumors in adults, are characterized by an aggressive local growth pattern and highly invasive tumor cells. This invasion is facilitated by expression of matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases. They mediate the degradation of protein components of the extracellular matrix. Twenty-three family members are known....