Article
Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status.
British journal of haematology - 1 May 1997
Egle A, Villunger A, Marschitz I, Kos M, Hittmair A, Lukas P, Grünewald K, Greil R
Abstract excerpt
The down-regulation of apoptosis may be an essential mechanism for tumour cell expansion in slowly proliferating tumours such as multiple myeloma. We studied eight myeloma cell lines for the presence of Bcl-2, which inhibits apoptosis, of Bax, which counteracts Bcl-2, of Bcl-x(L) and Bcl-x(S), wh...
Topics
- Apoptosis
- Flow Cytometry
- Humans
- Multiple Myeloma
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- bcl-2-Associated X Protein
- bcl-X Protein
- fas Receptor