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Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma

21 Sept 2018

Abstract excerpt

Chondrosarcomas are malignant cartilage tumors showing relative resistance to conventional chemo- and radiotherapy. Previous studies showed that chondrosarcoma cells could be sensitized to chemotherapy by inhibiting the Bcl-2 family members Bcl-2, Bcl-xl and Bcl-w using ABT-737. In this study we explored the specific role of Bcl-2 family members to identify the most important player in chondrosarcoma cell...

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PMID: 30242253
DOI: 10.1038/s41389-018-0084-0

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