Article
Host immunosurveillance contributes to the control of erbB-2 overexpression in HLA-A2-breast-cancer patients.
International journal of cancer - 22 Dec 1999
Nisticò P, Mottolese M, Cascioli S, Benevolo M, Del Bello D, Di Modugno F, Rubiu O, Gentile F P, Botti C, Venturo I, Natali P G
Abstract excerpt
Overexpression of gp185(erbB-2) has been associated with reduced survival in breast-cancer patients. Our earlier results, now confirmed in a larger cohort of patients (798), evidenced that the HLA-A2 allele may participate in the modulation of the erbB-2 tumor phenotype in vivo. In the present study, we evaluated other clinico-biopathologic parameters possibly involved in the host immune response against erbB-2....
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