Article
Effects of HLA status and HER2 status on outcomes in breast cancer patients at risk for recurrence - Implications for vaccine trial design.
Clinical immunology (Orlando, Fla.) - 1 Oct 2018
Jackson Doreen O, Trappey Francois A, Clifton G Travis, Vreeland Timothy J, Peace Kaitlin M, Hale Diane F, Litton Jennifer K, Murray James L, Perez Sonia A, Papamichail Michael, Mittendorf Elizabeth A, Peoples George E
Abstract excerpt
Immunotherapy, using peptide-based cancer vaccines is being studied to assess its potential in breast cancer. Trials of HLA-restricted peptide vaccines have been difficult to enroll given HLA subtype restrictions. It is necessary to determine the prognostic significance of HLA-status in breast cancer if patients who are ineligible to receive a vaccine due to their HLA-status are used as controls. The impact of...
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