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Article

Identification and functional analysis of novel inactivating thyrotropin receptor mutations in patients with thyrotropin resistance.

Thyroid : official journal of the American Thyroid Association - 1 May 2006

Tsunekawa Katsuhiko, Onigata Kazumichi, Morimura Tadashi, Kasahara Takayuki, Nishiyama Soroku, Kamoda Tomohito, Mori Masatomo, Morikawa Akihiro, Murakami Masami

Abstract excerpt

OBJECTIVE: We identified and analyzed novel thyrotropin (TSH) receptor mutations in three Japanese families with resistance to TSH. DESIGN: The TSH receptor gene was sequenced and the mutations were determined. The mutant TSH receptors were transfected into COS-7 cells, and their functions were a...

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Source

Identifiers

PMID: 16756469
DOI: 10.1089/thy.2006.16.471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16756469-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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