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Article

Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness.

Diabetologia - 1 Nov 1999

Fernández-Real J M, Ricart W

Abstract excerpt

AIMS/HYPOTHESIS: To describe a unifying hypothesis of the relation between insulin resistance and inflammatory response in the development of diabetes. METHODS: Review of the literature and authors' research. RESULTS: Infection and injury activate the immune system and bring about widespread metabolic changes which disadvantage and destroy the invading organism and facilitate repair of damaged tissue. Tumour...

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PMID: 10550422
DOI: 10.1007/s001250051451

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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