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Article

The influence of 5,10 methylenetetrahydrofolate reductase genotypes on enzyme activity in placental tissue.

British journal of obstetrics and gynaecology - 1 Nov 1999

Daly S F, Molloy A M, Mills J L, Lee Y J, Conley M, Kirke P N, Weir D G, Scott J M

Abstract excerpt

OBJECTIVE: To study the effects of heterozygosity and homozygosity for the C677T mutation of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene on the activity of this enzyme in placental tissue from pregnancies not affected by neural tube defect. DESIGN: Placental tissue was genotyped for the C677T variants of MTHFR. Total enzyme activity and residual activity after heating to 46 degrees C for 5 minutes...

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Source

Identifiers

PMID: 10549970
DOI: 10.1111/j.1471-0528.1999.tb08151.x

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The influence of 5,10 methylenetetrahydrofolate reductase genotypes on enzyme activity in placental tissue.PMID 10549970Read ↗

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5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.Semantic proximity Read ↗

The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.Semantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase (MTHFR) assay in the forward direction: residual activity in MTHFR deficiency.Semantic proximity Read ↗

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