Failure of HIV-1 protease inhibitors to fully suppress viral replication. Implications for salvage therapy.

Abstract excerpt

When used as initial therapy in combination with two nucleoside reverse transcriptase inhibitors, indinavir, ritonavir, nelfinavir and possible saquinavir-soft gel capsule (saquinavir-sgc) are highly effective agents. Patients who have been extensively pretreated, have advanced immunodeficiency or are unable to adhere with therapy are at high risk of failing protease inhibitor therapy. Although relevant...

Topics

• Acquired Immunodeficiency Syndrome
• HIV Infections
• HIV Protease
• HIV Protease Inhibitors
• HIV-1
• Humans
• Mutation
• Salvage Therapy
• Virus Replication