Article
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
Pancreas - 1 Mar 2006
Marchese Rodolfo, Muleti Alessandra, Pasqualetti Patrizio, Bucci Barbara, Stigliano Antonio, Brunetti Ercole, De Angelis Monica, Mazzoni Gianluca, Tocchi Adriano, Brozzetti Stefania
Abstract excerpt
OBJECTIVE: K-ras is the most frequently mutated gene in pancreatic cancer; reported rates range from 70% to 90%. The aim of this study was to evaluate the correspondence between K-ras mutations in pancreatic cancer tissue and in circulating DNA and the value of K-ras mutations as serological marker. METHODS: The research was conducted in 30 patients with pancreatic cancer in whom both plasma and neoplastic...
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