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Article

Protein folding in high-dimensional spaces: hypergutters and the role of nonnative interactions.

Biophysical journal - 1 Jan 2005

McLeish T C B

Abstract excerpt

We explore the consequences of very high dimensionality in the dynamical landscape of protein folding. Consideration of both typical range of stabilizing interactions, and folding rates themselves, leads to a model of the energy hypersurface that is characterized by the structure of diffusive "hypergutters" as well as the familiar "funnels". Several general predictions result: 1), intermediate subspaces of...

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Identifiers

PMID: 15501939
DOI: 10.1529/biophysj.103.036616
PMCID: PMC1304996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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