Article
Detection of Fetal-derived Paternally Inherited X-Chromosome Polymorphisms in Maternal Plasma
1 Nov 1999
Abstract excerpt
The recent demonstration of the presence of cell-free fetal DNA in the plasma and serum of pregnant women opens up new possibilities for noninvasive prenatal diagnosis (1)(2)(3)(4)(5). However, many published reports have used Y-chromosomal sequences that are present in a male fetus as a marker (1)(6)(7), an approach that is not applicable to the 50% of pregnancies that involve a female fetus. A marker allowing...
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