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Accuracy of Fetal Gender Determination by Analysis of DNA in Maternal Plasma

1 Oct 2001

Abstract excerpt

In 1997, Lo et al. (1) first described the presence of fetal DNA in maternal plasma and serum. Cell-free DNA offered a new source of fetal genetic material for noninvasive prenatal diagnosis. They developed a real-time, quantitative PCR assay to measure the concentration of fetal DNA and analyzed SRY, a single-copy Y-chromosome-specific sequence, to quantify the number of genome-equivalents per milliliter of...

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PMID: 11568102
DOI: 10.1093/clinchem/47.10.1856

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