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Article

Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression.

The Journal of biological chemistry - 9 Jan 2004

Jiang Bingbing, Xu Shanqin, Hou Xiuyun, Pimentel David R, Brecher Peter, Cohen Richard A

Abstract excerpt

In cultured rat vascular smooth muscle cells, sustained activation of ERK is required for interleukin-1beta to persistently activate NF-kappaB. Without ERK activation, interleukin-1beta induces only acute and transient NF-kappaB activation. The present study examined whether the temporal control of NF-kappaB activation by ERK could differentially regulate the expression of NF-kappaB-dependent genes, including...

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PMID: 14581482
DOI: 10.1074/jbc.M307521200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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