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Detection and quantitation by fluorescence in situ hybridization (FISH) and image analysis ofHER-2/neu gene amplification in breast cancer fine-needle samples

25 Oct 1999

Abstract excerpt

BACKGROUND: Fine-needle sampling, although a practical and noninvasive method of tissue acquisition, has rarely been used for HER-2/neu fluorescent in situ hybridization (FISH). To assess HER-2/neu gene amplification in mammary carcinoma, FISH signals on cytology and corresponding tissue biopsies were detected visually and measured by image analysis. The results were correlated with patient and tumor...

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PMID: 10536358
DOI: 10.1002/(sici)1097-0142(19991025)87:5<312::aid-cncr12>3.0.co;2-5

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