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Detection of HER-2/neu (c-erb B-2) DNA amplification in primary breast carcinoma

1 Jan 2001

Abstract excerpt

BACKGROUND: Fluorescent in situ hybridization (FISH) has been shown to be one of the most reliable methods with which to estimate the status of the HER-2/neu (or c-erb B-2) oncogene at the DNA level. METHODS: To study interobserver reproducibility and to determine more clinically correlated criteria for HER-2/neu alterations, two observers independently estimated HER-2/neu DNA status. The correlation between the...

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PMID: 11753973
DOI: 10.1002/1097-0142(20011215)92:12<2965::aid-cncr10156>3.0.co;2-a

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