Smad2 and Smad4 gene mutations in hepatocellular carcinoma.

doi:10.1038/sj.onc.1202866

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Article

Smad2 and Smad4 gene mutations in hepatocellular carcinoma.

Oncogene - 26 Aug 1999

Yakicier M C, Irmak M B, Romano A, Kew M, Ozturk M

Abstract excerpt

TGF-beta is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-beta pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were...

Topics

Base Sequence
Carcinoma, Hepatocellular
DNA-Binding Proteins
Gene Frequency
Genes, Tumor Suppressor
Humans
Liver Neoplasms
Molecular Sequence Data
Mutation
Signal Transduction
Smad2 Protein
Smad4 Protein
Trans-Activators
Transforming Growth Factor beta
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 10490821
DOI: 10.1038/sj.onc.1202866

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