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Article

Frequency of Smad gene mutations in human cancers.

Cancer research - 1 Jul 1997

Riggins G J, Kinzler K W, Vogelstein B, Thiagalingam S

Abstract excerpt

Much excitement has recently been generated by the discovery of the Smad genes, encoding proteins that transduce signals from the transforming growth factor beta family of cytokines. Here, we report the completion of cloning of the six known human Smads, providing novel sequences for Smad5 and Smad6. Previously, Smad4 and Smad2 were shown to be mutated in human cancers. However, analysis of the other four Smad...

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PMID: 9205057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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