Article

Genetically Corrected <i>RAG2</i> -SCID Human Hematopoietic Stem Cells Restore V(D)J-Recombinase and Rescue Lymphoid Deficiency

2022-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Recombination-activating genes ( RAG1 and RAG2 ) are critical in lymphoid cell development and function for initiating the V(D)J-recombination process to generate polyclonal lymphocytes with broad antigen-specificity. Clinical manifestations of defective RAG1/2 genes range from immune dysregulation to severe combined immunodeficiencies (SCID), causing life-threatening infections and death ear...

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Literature Corpus work: 08c6d3dc-b4a5-5a80-ab1e-85d92e397b89
DOI: 10.1101/2022.07.12.499831

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