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Article

Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome

1 Oct 2000

Abstract excerpt

Hereditary long QT syndrome (hLQTS) is a heterogeneous genetic disease characterized by prolonged QT interval in the electrocardiogram, recurrent syncope, and sudden cardiac death. Mutations in the cardiac potassium channel HERG (KCNH2) are the second most common form of hLQTS and reduce the delayed rectifier K(+) currents, thereby prolonging repolarization. We studied a novel COOH-terminal missense mutation,...

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Identifiers

PMID: 11009462
DOI: 10.1152/ajpheart.2000.279.4.h1748

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