Article
Rescue of mutated cardiac ion channels in inherited arrhythmia syndromes.
Journal of cardiovascular pharmacology - 1 Aug 2010
Balijepalli Sadguna Y, Anderson Corey L, Lin Eric C, January Craig T
Abstract excerpt
Inherited arrhythmia syndromes comprise an increasingly complex group of diseases involving mutations in multiple genes encoding ion channels, ion channel accessory subunits and channel interacting proteins, and various regulatory elements. These mutations serve to disrupt normal electrophysiology in the heart, leading to increased arrhythmogenic risk and death. These diseases have added impact as they often...
Topics
- Animals
- Arrhythmias, Cardiac
- Ether-A-Go-Go Potassium Channels
- Humans
- Ion Channels
- Long QT Syndrome
- Mutation
- Protein Transport