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Article

Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel.

PloS one - 1 Jan 2012

Harley Carol A, Jesus Catarina S H, Carvalho Ricardo, Brito Rui M M, Morais-Cabral João H

Abstract excerpt

Inherited human long-QT2 syndrome (LQTS) results from mutations in the gene encoding the HERG channel. Several LQT2-associated mutations have been mapped to the amino terminal cytoplasmic Per-Arnt-Sim (PAS) domain of the HERG1a channel subunit. Here we have characterized the trafficking properties of some LQT2-associated PAS domain mutants and analyzed rescue of the trafficking mutants by low temperature (27°C)...

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Source

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Identifiers

PMID: 22396785
DOI: 10.1371/journal.pone.0032654
PMCID: PMC3292575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel.PMID 22396785Read ↗

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Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels.Semantic proximity Read ↗

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