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Article

Identification of two serine residues involved in catalysis by fatty acid amide hydrolase.

Biochemical and biophysical research communications - 22 Oct 1999

Omeir R L, Arreaza G, Deutsch D G

Abstract excerpt

Fatty acid amide hydrolase is an integral membrane protein that hydrolyzes a novel and growing class of neuromodulatory fatty acid molecules, including anandamide, 2-arachidonyl glycerol, and oleamide. This activity is inhibited by serine and cysteine reactive agents, suggesting that the active site contains a serine or cysteine residue. Therefore serine and cysteine residues were mutated to alanine and the...

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Source

Identifiers

PMID: 10529361
DOI: 10.1006/bbrc.1999.1524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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