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Article

Structural and functional roles of highly conserved serines in human lipoprotein lipase. Evidence that serine 132 is essential for enzyme catalysis.

The Journal of biological chemistry - 25 May 1991

Faustinella F, Smith L C, Semenkovich C F, Chan L

Abstract excerpt

The structure of human lipoprotein lipase was recently deduced from its cDNA sequence. It contains 8 serine residues (residues 45, 132, 143, 172, 193, 244, 251, and 363) that are absolutely conserved in both lipoprotein lipase and hepatic lipase across all species studied. The high homology betwe...

Topics

Amino Acid Sequence
Binding Sites
Catalysis
DNA
Humans
Lipoprotein Lipase
Molecular Sequence Data
Mutation
Protein Conformation
Serine
Structure-Activity Relationship

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PMID: 1903387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1903387-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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