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Article

Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.

Toxicology and applied pharmacology - 15 Oct 1999

Li S, Wattenberg E V

Abstract excerpt

Palytoxin is a potent non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type skin tumor promoter. We used COS7 and HeLa cells to investigate the protein kinase cascades by which palytoxin activates the mitogen-activated protein kinase (MAPK) p38. Three p38 kinases have been identified: stress-activated protein kinase/extracellular signal-regulated kinase kinase-1 (SEK1), MAPK kinase 3 (MKK3), and MKK6. SEK1...

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Identifiers

PMID: 10527909
DOI: 10.1006/taap.1999.8754

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