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Article

Transdifferentiation of prostate cancer cells to a neuroendocrine cell phenotype in vitro and in vivo.

The Journal of urology - 1 Nov 1999

Burchardt T, Burchardt M, Chen M W, Cao Y, de la Taille A, Shabsigh A, Hayek O, Dorai T, Buttyan R

Abstract excerpt

PURPOSE: To better understand the source of neuroendocrine cells associated with human prostate cancer progression, we studied the ability of a cultured prostate cancer cell line, LNCaP, to transdifferentiate into neuroendocrine-like cells in vitro and in vivo. MATERIALS AND METHODS: Cyclic AMP concentrations were measured in extracts of LNCaP cells cultured in the presence of normal or hormone-deficient medium...

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PMID: 10524938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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