Article
Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.
Molecular psychiatry - 1 Sept 1999
Rhoads A R, Karkera J D, Detera-Wadleigh S D
Abstract excerpt
Lithium, an effective drug in the treatment of bipolar disorder, has been proposed to disrupt the Wnt signaling pathway. To facilitate analysis of the possible involvement of elements of the Wnt pathway in human bipolar disorder, a high resolution radiation hybrid mapping (RHM) of these genes was performed. A fine physical location has been obtained for Wnt 7A, frizzled 3, 4 and 5, dishevelled 1, 2 and 3,...
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