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Article

The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia

1 Sept 1999

Abstract excerpt

To clarify the role of p53 in the killing of chronic lymphocytic leukaemia (CLL) cells by purine analogues, we examined the cytotoxic effects of chlorodeoxyadenosine and fludarabine on CLL cells that had been characterized according to their p53 functional status. Cases of CLL with p53 dysfunction (n = 7) displayed slight, but significant, resistance to nucleoside-induced cell killing when compared with cases...

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PMID: 10520012
DOI: 10.1046/j.1365-2141.1999.01649.x

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