Article
In vitro chemosensitivity of chronic lymphocytic leukaemia to purine analogues--correlation with clinical course.
Leukemia - 1 Aug 1998
Bromidge T J, Turner D L, Howe D J, Johnson S A, Rule S A
Abstract excerpt
Samples from 51 chronic lymphocytic leukaemia (CLL) patients (42 typical, nine atypical) were assessed for in vitro response to fludarabine and cladribine (2-CdA) using the flow cytometric terminal deoxynucleotidyl transferase (TdT) assay. No difference was demonstrated between the in vitro respo...
Topics
- Antineoplastic Agents
- Apoptosis
- Cladribine
- DNA Nucleotidylexotransferase
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Flow Cytometry
- Humans
- In Vitro Techniques
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphocytes
- Phenotype
- Proto-Oncogene Proteins c-bcl-2
- Vidarabine