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Article

NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery.

Biopolymers - 1 Jan 1999

Moore J M

Abstract excerpt

Over the last ten years, nmr spectroscopy has evolved into an important discipline in drug discovery. Initially, nmr was most useful as a technique to provide structural information regarding protein drug targets and target-ligand interactions. More recently, it has been shown that nmr may be used as an alternative method for identification of small molecule ligands that bind to protein drug targets. High...

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PMID: 10516573
DOI: 10.1002/(SICI)1097-0282(1999)51:3<221::AID-BIP5>3.0.CO;2-9

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