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Article

Sequence-specific 1H and 15N resonance assignments for human dihydrofolate reductase in solution.

Biochemistry - 14 Jan 1992

Stockman B J, Nirmala N R, Wagner G, Delcamp T J, DeYarman M T, Freisheim J H

Abstract excerpt

Dihydrofolate reductase is an intracellular target enzyme for folate antagonists, including the anticancer drug methotrexate. In order to design novel drugs with altered binding properties, a detailed description of protein-drug interactions in solution is desirable to understand the specificity of drug binding. As a first step in this process, heteronuclear three-dimensional NMR spectroscopy has been used to...

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Identifiers

PMID: 1731871
DOI: 10.1021/bi00116a031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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