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Article

Molecular modelling indicates that the pathological conformations of prion proteins might be beta-helical.

The Biochemical journal - 15 Oct 1999

Downing D T, Lazo N D

Abstract excerpt

Creutzfeldt-Jakob disease, kuru, scrapie and bovine spongiform encephalopathy are diseases of the mammalian central nervous system that involve the conversion of a cellular protein into an insoluble extracellular isoform. Spectroscopic studies have shown that the precursor protein contains mainly alpha-helical and random-coil conformations, whereas the prion isoform is largely in the beta conformation. The...

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Identifiers

PMID: 10510313
PMCID: PMC1220574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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