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Article

Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis.

Biological psychiatry - 1 Oct 1999

Seidman L J, Faraone S V, Goldstein J M, Goodman J M, Kremen W S, Toomey R, Tourville J, Kennedy D, Makris N, Caviness V S, Tsuang M T

Abstract excerpt

BACKGROUND: Schizophrenia is characterized by subcortical and cortical brain abnormalities. Evidence indicates that some nonpsychotic relatives of schizophrenic patients manifest biobehavioral abnormalities, including brain abnormalities. The goal of this study was to determine whether amygdala-hippocampal and thalamic abnormalities are present in relatives of schizophrenic patients. METHODS: Subjects were 28...

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PMID: 10509177
DOI: 10.1016/s0006-3223(99)00075-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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