Article
Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives.
Archives of general psychiatry - 1 Sept 2002
Seidman Larry J, Faraone Stephen V, Goldstein Jill M, Kremen William S, Horton Nicholas J, Makris Nikos, Toomey Rosemary, Kennedy David, Caviness Verne S, Tsuang Ming T
Abstract excerpt
BACKGROUND: Clues to the causes of schizophrenia can be derived from studying first-degree relatives because they are genetically related to an ill family member. Abnormalities observed in nonpsychotic relatives are indicators of possible genetic vulnerability to illness, independent of psychosis. We tested 4 hypotheses: (1) that hippocampal volume is smaller in nonpsychotic relatives than in controls,...
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