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Article

DNA contacts by protein domains of the molluscum contagiosum virus type-1B topoisomerase.

Virology - 30 Sept 1999

Hwang Y, Park M, Fischer W H, Burgin A, Bushman F

Abstract excerpt

All poxviruses studied encode a type 1B topoisomerase that introduces transient nicks into DNA and thereby relaxes DNA supercoils. Here we present a study of the protein domains of the topoisomerase of the poxvirus molluscum contagiosum (MCV), which allows us to specify DNA contacts made by different domains. Partial proteolysis of the enzyme revealed two stable domains separated by a protease-sensitive linker. A...

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Share to Catalytic Domain
Share to Conserved Sequence
Share to DNA, Superhelical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

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Share to Regulatory Sequences, Nucleic Acid

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Source

Identifiers

PMID: 10502526
DOI: 10.1006/viro.1999.9920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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