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A poxvirus-like type IB topoisomerase family in bacteria

5 Feb 2002

Abstract excerpt

We report that diverse species of bacteria encode a type IB DNA topoisomerase that resembles vaccinia virus topoisomerase. Deinococcus radiodurans topoisomerase IB (DraTopIB), an exemplary member of this family, relaxes supercoiled DNA in the absence of a divalent cation or ATP. DraTopIB has a compact size (346 aa) and is a monomer in solution. Mutational analysis shows that the active site of DraTopIB is...

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PMID: 11830640
DOI: 10.1073/pnas.032613199

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