Article
Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1999
Archer G E, Sampson J H, Lorimer I A, McLendon R E, Kuan C T, Friedman A H, Friedman H S, Pastan I H, Bigner D D
Abstract excerpt
The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by primary brain tumors or by hematogeneous spread of systemic solid tumors. A frequent genetic alteration in primary brain tumors such as gliomas is an in-frame deletion in the epidermal growth factor receptor (EGFR) gene EGFRvIII, which brings together what were normally distant...
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