Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia.

Blood - 1 Oct 1999

Asimakopoulos F A, Shteper P J, Krichevsky S, Fibach E, Polliack A, Rachmilewitz E, Ben-Neriah Y, Ben-Yehuda D

Abstract excerpt

Methylation of the proximal promoter of the ABL1 oncogene is a common epigenetic alteration associated with clinical progression of chronic myeloid leukemia (CML). In this study we queried whether both the Ph'-associated and normal ABL1 alleles undergo methylation; what may be the proportion of hematopoietic progenitors bearing methylated ABL1 promoters in chronic versus acute phase disease; whether methylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blast Crisis
Share to Dinucleoside Phosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Genes, abl

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Oncogenes

Share to Philadelphia Chromosome

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10498618

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia.PMID 10498618Read ↗

The role of methylation in CML.Semantic proximity Read ↗

Epigenetic Reprogramming and Emerging Epigenetic Therapies in CMLSemantic proximity Read ↗

Genome-wide DNA methylation in chronic myeloid leukaemiaSemantic proximity Read ↗

Genomic profile of chronic myelogenous leukemia: Imbalances associated with disease progressionSemantic proximity Read ↗

Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implicationsSemantic proximity Read ↗

BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia.Semantic proximity Read ↗

Aberrant methylation in promoter-associated CpG islands of multiple genes in chronic myelogenous leukemia blast crisisSemantic proximity Read ↗

Detection of methylated ABL1 promoter in philadelphia-negative myeloproliferative disorders.Semantic proximity Read ↗

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status.Semantic proximity Read ↗

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.Semantic proximity Read ↗

Chromosome Band 1p36 Contains a Putative Tumor Suppressor Gene Important in the Evolution of Chronic Myelocytic LeukemiaSemantic proximity Read ↗

Aberrant DNA Methylation Is Associated with Disease Progression, Resistance to Imatinib and Shortened Survival in Chronic Myelogenous LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.