Article
A pore segment in DEG/ENaC Na(+) channels.
The Journal of biological chemistry - 1 Oct 1999
Snyder P M, Olson D R, Bucher D B
Abstract excerpt
DEG/ENaC Na(+) channels have diverse functions, including Na(+) absorption, neurotransmission, and sensory transduction. The ability of these channels to discriminate between different ions is critical for their normal function. Several findings suggest that DEG/ENaC channels have a pore structure similar to K(+) channels. To test this hypothesis, we examined the accessibility of native and introduced cysteines...
Topics
- Amino Acid Sequence
- Cysteine
- Epithelial Sodium Channels
- Ethyl Methanesulfonate
- Humans
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Sodium Channels