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Article

Phase variation in Helicobacter pylori lipopolysaccharide due to changes in the lengths of poly(C) tracts in alpha3-fucosyltransferase genes.

Infection and immunity - 1 Oct 1999

Appelmelk B J, Martin S L, Monteiro M A, Clayton C A, McColm A A, Zheng P, Verboom T, Maaskant J J, van den Eijnden D H, Hokke C H, Perry M B, Vandenbroucke-Grauls C M, Kusters J G

Abstract excerpt

The lipopolysaccharide (LPS) of Helicobacter pylori expresses the Lewis x (Lex) and/or Ley antigen. We have shown previously that H. pylori LPS displays phase variation whereby an Lex-positive strain yields variants with different LPS serotypes, for example, Lex plus Ley or nonfucosylated polylactosamine. H. pylori has two alpha3-fucosyltransferase genes that both contain poly(C) tracts. We now demonstrate that...

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Identifiers

PMID: 10496917
DOI: 10.1128/IAI.67.10.5361-5366.1999
PMCID: PMC96892

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Source receipt: pubmed, retrieved 7 Sept 2026.

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