Article
Molecular genetic basis for the variable expression of Lewis Y antigen in <i>Helicobacter pylori</i> : analysis of the α(1,2) fucosyltransferase gene
1 Feb 1999
Abstract excerpt
Helicobacter pylori lipopolysaccharides (LPS) express human oncofetal antigens Lewis X and Lewis Y. The synthesis of Lewis Y involves the actions of alpha (1,3) and alpha (1,2) fucosyltransferases (FucTs). Here, we report the molecular cloning and characterization of genes encoding H. pylori alpha (1,2) FucT (Hp fucT2) from various H. pylori strains. We constructed Hp fucT2 knock-out mutants and demonstrated the...
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