Article
Phase variation in Helicobacter pylori lipopolysaccharide.
Infection and immunity - 1 Jan 1998
Appelmelk B J, Shiberu B, Trinks C, Tapsi N, Zheng P Y, Verboom T, Maaskant J, Hokke C H, Schiphorst W E, Blanchard D, Simoons-Smit I M, van den Eijnden D H, Vandenbroucke-Grauls C M
Abstract excerpt
Helicobacter pylori NCTC 11637 lipopolysaccharide (LPS) expresses the human blood group antigen Lewis x (Le(x)) in a polymeric form. Le(x) is beta-D-galactose-(1-4)-[alpha-L-fucose-(1-3)]-beta-D-acetylglucosamine. Schematically the LPS structure is (Le(x))n-core-lipid A. In this report, we show that Le(x) expression is not a stable trait but that LPS displays a high frequency (0.2 to 0.5%) of phase variation,...
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