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Article

Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy.

Tissue antigens - 1 Aug 1999

Hohjoh H, Nakayama T, Ohashi J, Miyagawa T, Tanaka H, Akaza T, Honda Y, Juji T, Tokunaga K

Abstract excerpt

Narcolepsy is a sleep disorder in which multiple factors, including environmental and genetic factors, are involved. A genetic factor strongly associated with the disorder has been found in the human leukocyte antigen (HLA) class II region: the haplotype, DRB1*1501-DQB1*0602, predisposes to narcolepsy. No susceptibility genes other than the HLA-haplotype have been found. In this paper, we performed an association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Polymorphism, Single-Stranded Conformational

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 10488740
DOI: 10.1034/j.1399-0039.1999.540204.x

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy.PMID 10488740Read ↗

Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families.Semantic proximity Read ↗

TNFA promoter polymorphisms and narcolepsy.Semantic proximity Read ↗

Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and -DQB1*0602.Semantic proximity Read ↗

Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: No association with narcolepsy.Semantic proximity Read ↗

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.Semantic proximity Read ↗

Increased plasma level of tumor necrosis factor α in patients with narcolepsy in Taiwan.Semantic proximity Read ↗

Negative association of the HLA-DRB1*1502-DQB1*0601 haplotype with human narcolepsy.Semantic proximity Read ↗

Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype.Semantic proximity Read ↗

Use of PCR with sequence-specific primers for high-resolution human leukocyte antigen typing of patients with narcolepsy.Semantic proximity Read ↗

Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study.Semantic proximity Read ↗

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