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Article

Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: No association with narcolepsy.

American journal of medical genetics - 20 Aug 1999

Kato T, Honda M, Kuwata S, Juji T, Kunugi H, Nanko S, Fukuda M, Honda Y

Abstract excerpt

The striking evidence of almost 100% association of narcolepsy with human leukocyte antigens (HLA) DR2(DR15) antigen is an important clue to elucidate the molecular basis of this sleep disorder. The gene for tumor necrosis factor alpha (TNF alpha) is located in the HLA class II gene cluster. Recent studies have indicated that TNF alpha plays an important role in the regulation of normal human sleep, and...

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Source

Identifiers

PMID: 10402494
DOI: 10.1002/(sici)1096-8628(19990820)88:4<301::aid-ajmg4>3.0.co;2-3

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: No association with narcolepsy.PMID 10402494Read ↗

TNFA promoter polymorphisms and narcolepsy.Semantic proximity Read ↗

Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy.Semantic proximity Read ↗

Increased plasma level of tumor necrosis factor α in patients with narcolepsy in Taiwan.Semantic proximity Read ↗

Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families.Semantic proximity Read ↗

A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms.Semantic proximity Read ↗

Evaluation of the associations between the single nucleotide polymorphisms of the promoter region of the tumor necrosis factor-alpha gene and nasopharyngeal carcinoma.Semantic proximity Read ↗

Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups.Semantic proximity Read ↗

Analysis of tumor necrosis factor-alpha gene promoter polymorphisms in anorexia nervosa.Semantic proximity Read ↗

Promoter variation of tumour necrosis factor-alpha gene: possible high risk for chronic bronchitis but not diffuse panbronchiolitis.Semantic proximity Read ↗

Myasthenia gravis and tumor necrosis factor beta polymorphisms: linkage disequilibrium but no association beyond HLA-B8.Semantic proximity Read ↗

Tumor necrosis factor polymorphism in multiple sclerosis: no additional association independent of HLA.Semantic proximity Read ↗

Tumour necrosis factor-α gene promoter polymorphism in chronic obstructive pulmonary diseaseSemantic proximity Read ↗

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