Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype.

doi:10.1038/jhg.2009.118

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Article

Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB11501-DQB10602 haplotype.

Journal of human genetics - 1 Jan 2010

Miyagawa Taku, Honda Makoto, Kawashima Minae, Shimada Mihoko, Tanaka Susumu, Honda Yutaka, Tokunaga Katsushi

Abstract excerpt

Essential hypersomnia (EHS) exhibits excessive daytime sleepiness without cataplexy and is associated with the HLA-DRB1*1501-DQB1*0602 haplotype, similar to narcolepsy with cataplexy. Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor alpha (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy. We investigated whether the SNP...

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PMID: 19927159
DOI: 10.1038/jhg.2009.118

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