Article
(TTA)n repeat polymorphism in the HMG-CoA reductase gene and cholesterolaemia.
VASA. Zeitschrift fur Gefasskrankheiten - 1 Aug 1999
Hubacek J A, Pistulková H, Valenta Z, Poledne R
Abstract excerpt
BACKGROUND: Hypercholesterolaemia is one of the main risk factors of atherosclerosis. Both environmental and genetic factors have been implicated in the development of hypercholesterolaemia. The enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase plays an important role in cholesterol synthesis. Thus we supposed that polymorphisms in this gene could influence cholesterolaemia. PATIENTS AND METHODS: Using...
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