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SV40 and human mesothelioma

1 Feb 2020

Abstract excerpt

. Hamsters injected intracardially to expose most tissue types to SV40 preferentially develop mesotheliomas. In humans, asbestos is the main cause of mesothelioma, and asbestos and SV40 are co-carcinogens in transforming HM cells in tissue culture and in causing mesothelioma in hamsters. Laser microdissection experiments conducted in the laboratory of Adi Gazdar demonstrated that SV40 was present specifically in...

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PMID: 32206570
DOI: 10.21037/tlcr.2020.02.03

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